U.S. Highway 101, the major north-south coastal highway, runs through both Coos Bay and North Bend. The area is linked to Interstate 5 via state highways 42 (Coos Bay to Roseburg), 38 (Reedsport to I-5 at Curtin) and 126 (Florence to Eugene).

The Southwest Oregon Regional Airport is served by Horizon Air, providing northbound passenger service to Portland, and a variety of freight carriers. Charter air services are also available. Navigation aids include ILS, VOR, MLS and GPS. Aircraft operations average nearly 60,000 per year.

Central Oregon and Pacific Railroad provides freight service connecting the Bay Area to the national rail system. Major shipments include approximately 6,000 carloads of paper products and wood products, including plywood and lumber.

The Oregon International Port of Coos Bay is the public port authority for the Bay Area, operating in partnership with private sector firms which own and operate cargo terminals and provide marine services. Total commerce through the Harbor in 2000 was more than 2.6 million short tons, comprised mostly of wood products and wood fiber.

A variety of trucking companies operate in the Bay Area, providing scheduled freight shipments, as well as overnight express mail and parcel services.

 Porter Stage Lines provides scheduled passenger and freight bus services in the Bay Area. Charter services are also available through North Bend Bus Company and Laidlaw Transit.

Other public transportation is provided through the Coos County Area Transit program and private taxi services.